The Claim
In patients with progressive supranuclear palsy and corticobasal syndrome, higher glycemic variability, measured as the coefficient of variation in glucose levels during oral glucose tolerance tests, is associated with worse performance on cognitive tests including the Montreal Cognitive Assessment, Mini-Mental State Examination, and Frontal Assessment Battery, independent of age and sex, even in individuals without diabetes.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In patients with progressive supranuclear palsy and corticobasal syndrome, greater fluctuations in blood glucose levels during a glucose tolerance test are linked to lower scores on cognitive tests, regardless of diabetes status, age, or sex.
See the scientific wording
In patients with progressive supranuclear palsy and corticobasal syndrome, higher glycemic variability—measured as coefficient of variation in glucose levels during oral glucose tolerance tests—is associated with worse performance on cognitive tests including the Montreal Cognitive Assessment, Mini-Mental State Examination, and Frontal Assessment Battery, independent of age and sex, even in individuals without diabetes.
Large swings in blood sugar damage small blood vessels in the brain, causing oxygen and nutrient shortages that kill brain cells in memory and thinking areas. At the same time, the brain receives less insulin, which normally protects neurons and keeps chemical signals balanced. Without this protection, brain cells die faster and communication between them breaks down, making memory and decision-making worse.
What the research says
1 studyIn people with rare brain diseases like PSP and CBS, bigger spikes and drops in blood sugar after eating were linked to worse memory and thinking test scores — even if they didn’t have diabetes.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.