Turning on a protein called AMPK tells another protein, PPARα, to switch on genes that help the body burn fat for energy.

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Evidence from Studies

Supporting (2)

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ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis

Cross-Sectional Study

Animal & In Vitro

2024 Feb 23

Acetic Acid Influences BRL-3A Cell Lipid Metabolism via the AMPK Signalling Pathway

Cross-Sectional Study

In Vitro

1979 Apr

Contradicting (0)

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No contradicting evidence found

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Similar Assertions

A protein in your body called AMPK helps control how fat is burned and made, so fixing how it works might help treat obesity and related health problems.

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In cow liver cells, a substance called acetate boosts a protein that helps burn fat, and the more acetate you add, the stronger the effect — but this only happens when another key energy-sensing switch is turned on.

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Acetate turns up fat-burning genes in liver cells, but only when a specific switch called AMPK is working — if we turn off that switch, the effect goes away.

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Your body needs to keep turning on a protein called PPARα for a long time to grow more energy factories in your cells and get better at burning fat over the long haul.

71%

In mice eating a bad diet, a drug called GW501516 might help keep a key energy-sensing switch in the liver working properly, which could help their bodies handle the stress of unhealthy eating.

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