Certain antibodies produced in response to proteins in wheat may bind to human proteins found in the thyroid, muscles, and other tissues, which could potentially trigger immune responses against the body's own tissues in some individuals.

48

Pro

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Against

Evidence from Studies

Supporting (1)

48

Community contributions welcome

48

Reaction of Lectin-Specific Antibody with Human Tissue: Possible Contributions to Autoimmunity

Cross-Sectional Study

Human

2020

This study found that antibodies made against certain plant proteins (like those in wheat and beans) also stick to human body proteins, like those in the thyroid and muscles. This could trick the immune system into attacking the body by mistake, which might explain some autoimmune diseases.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Reaction of Lectin-Specific Antibody with Human Tissue: Possible Contributions to Autoimmunity

Score: 48

DOI: 10.1155/2020/1438957

Similar Assertions

Antibodies designed to target one plant protein can sometimes bind to other similar plant proteins because they share structural features, leading to reactions beyond their intended target.

48

0

74%

Some proteins found in beans and wheat may increase leakage in the gut lining and trigger inflammation in laboratory models, which could potentially lead to autoimmune reactions via specific biological pathways involving molecular mimicry and the NLRP3 inflammasome.

1

0

73%