The Claim
Apigenin inhibits the NAD+ase enzyme CD38 in mouse liver tissue and cultured cells, resulting in increased intracellular NAD+ levels and reduced global protein acetylation, which is associated with improved glucose tolerance and reduced liver triglycerides in obese mice fed a high-fat diet.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Apigenin reduces the activity of the CD38 enzyme in mouse liver and cells, which increases NAD+ levels and decreases protein acetylation, leading to better glucose control and lower liver fat in obese mice on a high-fat diet.
See the scientific wording
Apigenin, a flavonoid, inhibits the NAD+ase enzyme CD38 in mouse liver tissue and cultured cells, leading to increased intracellular NAD+ levels and reduced global protein acetylation, which correlates with improved glucose tolerance and reduced liver triglycerides in obese mice fed a high-fat diet.
Apigenin blocks an enzyme called CD38 in the liver, which lets NAD+ levels rise. Higher NAD+ turns on a protein called SIRT1 that removes acetyl groups from other proteins. This turns on genes that break down fats and improves how the body handles sugar, reducing fat buildup in the liver and lowering blood sugar.
What the research says
1 studyStudy: Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38
Apigenin, a natural compound, blocks an enzyme called CD38 in obese mice, which helps raise a helpful molecule (NAD+) in their liver. This leads to less fat buildup and better blood sugar control, exactly as the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.