The Claim
Apigenin activates SIRT1 and enhances the NAD+/NADH ratio, resulting in metabolic effects analogous to caloric restriction.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Apigenin increases SIRT1 activity and raises the NAD+/NADH ratio, producing metabolic changes similar to those caused by reducing calorie intake.
See the scientific wording
Apigenin activates SIRT1 and enhances the NAD+/NADH ratio, producing metabolic effects analogous to caloric restriction.
Apigenin blocks an enzyme that breaks down NAD+, causing NAD+ levels to rise. Higher NAD+ turns on a protein that removes acetyl groups from metabolic regulators, which switches the body to burn fat instead of storing it and improves how it handles sugar.
What the research says
1 studyStudy: Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38
Apigenin, a compound in some plants, helps boost a key molecule (NAD+) in the liver of obese mice, which in turn turns on a cellular cleanup system (SIRT1) that improves blood sugar and reduces fat — just like fasting does.
Related videos
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.