The Claim
Apigenin inhibits the NAD+-degrading enzyme CD38, leading to increased intracellular NAD+ levels and improved NAD+/NADH ratio.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Apigenin reduces the activity of the enzyme CD38, which results in higher levels of NAD+ inside cells and a higher ratio of NAD+ to NADH.
See the scientific wording
Apigenin inhibits the NAD+-degrading enzyme CD38, leading to increased intracellular NAD+ levels and improved NAD+/NADH ratio.
Apigenin blocks an enzyme that breaks down NAD+, causing NAD+ levels to rise inside cells. Higher NAD+ levels shift the balance between NAD+ and NADH toward more NAD+, which improves how cells produce and use energy.
What the research says
1 studyStudy: Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38
Apigenin, a compound found in some plants, blocks an enzyme called CD38 that breaks down NAD+, a molecule your cells need for energy. When CD38 is blocked, NAD+ levels go up, helping cells work better — and the study showed this actually happens in mice.
Related videos
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.