The Claim
Apigenin increases intracellular NAD+ levels in mouse cells and tissues in a CD38-dependent manner, as evidenced by the absence of this effect in CD38 knockout cells.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Apigenin raises the amount of NAD+ inside mouse cells and tissues, and this increase requires the presence of the CD38 protein.
See the scientific wording
Apigenin increases intracellular NAD+ levels in mouse cells and tissues in a CD38-dependent manner, as evidenced by the absence of this effect in CD38 knockout cells.
Apigenin blocks the enzyme that breaks down NAD+, causing NAD+ to build up inside cells. More NAD+ means the cell can activate processes that use it, like repairing DNA and regulating metabolism.
What the research says
1 studyStudy: Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38
Apigenin boosts NAD+ levels in mouse cells by blocking the CD38 enzyme that breaks down NAD+. If CD38 isn’t there, apigenin can’t work — so it only raises NAD+ when CD38 is present.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.