Berberine, a natural compound, tells your liver to grab more bad cholesterol (LDL) out of your blood by turning on a cellular energy sensor, helping lower your cholesterol levels.

This study didn’t test berberine directly, but a close cousin of it that works even better — and it showed that this cousin turns on a cellular energy sensor (AMPK), which helps the liver remove bad cholesterol from the blood. So yes, it supports the idea that berberine-like compounds do this.

The study found that berberine, a compound in a herbal remedy, helps the liver remove bad cholesterol from the blood by making more receptors for it — which is exactly what the claim says. Even though it didn’t test the exact energy pathway mentioned, the main result matches.