Berberine, a natural compound, may help lower fat in your blood by turning on a cellular switch that stops your body from making new fat and starts burning existing fat instead—this has been seen in lab tests and animals, but not yet confirmed in humans.

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Evidence from Studies

Supporting (1)

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Update on the Benefits and Mechanisms of Action of the Bioactive Vegetal Alkaloid Berberine on Lipid Metabolism and Homeostasis

Narrative Review

Human

2018

This study looks at how a natural compound called berberine affects fat levels in the body, and it says it works by changing how the body makes and burns fat—just like the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Update on the Benefits and Mechanisms of Action of the Bioactive Vegetal Alkaloid Berberine on Lipid Metabolism and Homeostasis

Score: 1

DOI: 10.1155/2018/7173920

Similar Assertions

Berberine, a natural compound, tells your liver to grab more bad cholesterol (LDL) out of your blood by turning on a cellular energy sensor, helping lower your cholesterol levels.

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Taking berberine pills for 3 months helped people with high cholesterol lower their bad fats in the blood—cholesterol dropped by almost a third, and triglycerides by over a third—so it might be a natural way to help manage cholesterol.

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Taking berberine pills (500 mg, 2–3 times a day) can help lower your bad cholesterol and fat levels in the blood almost as well as a low dose of statin drugs, and it might work by turning on a cellular switch that helps your body remove more bad cholesterol.

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Berberine, a natural compound, may help lower bad cholesterol by helping your liver grab more of it from your blood—kind of like turning up a vacuum cleaner that sucks up cholesterol, thanks to how it blocks a protein called PCSK9 and keeps the cholesterol sensors in your liver working longer.

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Taking berberine pills every day for 3 months can lower your bad cholesterol and fat levels in the blood by a lot—like cutting your cholesterol by nearly a third.

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