In obese adults following supervised diet and exercise programs designed to create a calorie deficit, 5% to 20% do not lose weight and may even gain weight, even when they follow the plan closely, suggesting that biological differences between individuals affect how well these standard approaches work.

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About Unsuccessful Responders to Diet and Physical Activity Interventions: A Focus on Energy Balance and Body-Weight Loss

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Human

2026 Jan 7

Even when people follow diet and exercise plans exactly, some still gain weight or don’t lose any—this study says it’s because everyone’s body reacts differently due to genetics and biology, not because they’re not trying.

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About Unsuccessful Responders to Diet and Physical Activity Interventions: A Focus on Energy Balance and Body-Weight Loss

Score: 1

DOI: 10.3390/nu18020195

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