Big, chunky molecules of hyaluronic acid are easier for certain good bacteria in your gut to break down and eat than smaller ones.

Pro

Against

Evidence from Studies

Supporting (1)

Community contributions welcome

Degradation and fermentation of hyaluronic acid by Bacteroides spp. from the human gut microbiota.

Cross-Sectional Study

In Vitro

2024 Jun 15

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Degradation and fermentation of hyaluronic acid by Bacteroides spp. from the human gut microbiota.

Score: 3

DOI: 10.1016/j.carbpol.2024.122074

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Some good bacteria in your gut can break down a substance called hyaluronic acid, and different strains do it in different ways—some even share the broken-down pieces with other bacteria, like one bacteria passing along a chemical called UDP4.

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A specific type of gut bacteria called Bacteroides salyersiae is better at breaking down a substance called hyaluronic acid—no matter if it’s big or small molecules—than other similar bacteria we’ve looked at.

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A specific gut bacteria called Bacteroides salyersiae breaks down a substance in your body called hyaluronic acid and makes a small sugar molecule called udp4 as a result.

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In mice, certain good bacteria in the gut called Bacteroides are needed to help the body soak up a substance called hyaluronan when it's swallowed.

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