mechanistic
Analysis v1
Strong Support
When healthy adults get a certain drug in their leg artery, blood flow drops by up to 45%, and insulin makes this drop even bigger — showing that insulin helps control blood flow in muscles by affecting nitric oxide.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.
Cross-Sectional Study
Human
1994 SepThe study gave a substance that blocks nitric oxide in the leg artery and found blood flow dropped more when insulin was present, just like the claim says.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.