When healthy adults get a certain drug in their leg artery, blood flow drops by up to 45%, and insulin makes this drop even bigger — showing that insulin helps control blood flow in muscles by...

Pro

Against

Evidence from Studies

Supporting (1)

Community contributions welcome

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

Cross-Sectional Study

Human

1994 Sep

Contradicting (0)

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

Score: 38

DOI: 10.1172/JCI117433

Similar Assertions

When insulin levels go up in healthy adults, it helps blood flow better in the legs by turning on a molecule called nitric oxide — and it works about twice as well as when insulin isn’t active.

73%

In healthy people, a substance in blood vessels called nitric oxide helps keep blood pressure and vessel tightness in check. When scientists blocked this substance, blood vessels tightened up and blood pressure went up, showing how important it is for keeping things normal.

70%