The Claim
In healthy adult humans, intra-arterial infusion of L-NMMA at a rate of 16 mg/min reduces leg blood flow by 20–45%, and this reduction is significantly greater during hyperinsulinemia compared to saline infusion, indicating that insulin enhances the basal contribution of nitric oxide to skeletal muscle perfusion.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When healthy adults get a certain drug in their leg artery, blood flow drops by up to 45%, and insulin makes this drop even bigger — showing that insulin helps control blood flow in muscles by affecting nitric oxide.
See the scientific wording
In healthy adult humans, intra-arterial infusion of L-NMMA at 16 mg/min reduces leg blood flow by 20–45%, with a significantly greater reduction observed during hyperinsulinemia compared to saline infusion, demonstrating that insulin augments the basal contribution of nitric oxide to skeletal muscle perfusion.
What the research says
1 studyThe study gave a substance that blocks nitric oxide in the leg artery and found blood flow dropped more when insulin was present, just like the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.