The Claim

Intermittent fasting and caloric restriction reduce circulating levels of insulin-like growth factor 1 (IGF-1) in healthy adults, and a three‑month fasting‑mimicking diet administered in three cycles lowers IGF-1 levels, suggesting this reduction may be a mechanism for decreasing cancer risk because IGF-1 promotes tumor growth and cell proliferation.

Source: Impact of Intermittent Fasting and/or Caloric Restriction on Aging-Related Outcomes in Adults: A Scoping Review of Randomized Controlled Trials

What the research says

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Supports
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Challenges
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These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
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In plain English

Skipping meals or eating fewer calories can lower a hormone called IGF‑1 in healthy people, and doing a special three‑month diet three times does the same, which might help lower cancer risk.

See the scientific wording

Intermittent fasting and caloric restriction reduce circulating levels of insulin-like growth factor 1 (IGF-1) in healthy adults, with a 3-month fasting-mimicking diet regimen lowering IGF-1 levels across three cycles, suggesting a potential mechanism for cancer risk reduction given IGF-1's role in tumor promotion and cell proliferation.

Score breakdown, mechanism chain, raw evidence, ideal studies needed

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