The Claim

Adolescents with nonsuicidal self-injury and comorbid depression exhibit significant hypoactivation of the ventral striatum during reward anticipation.

Source: Beyond distress relief: the Anhedonic Subtype of nonsuicidal self-injury and the imperative for Positive Affect Treatment

What the research says

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Supports
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Challenges
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These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Adolescents who engage in nonsuicidal self-injury and have depression show reduced activity in the ventral striatum when expecting a reward.

See the scientific wording

Neuroimaging studies consistently show that adolescents with nonsuicidal self-injury and comorbid depression exhibit significant hypoactivation of the ventral striatum during reward anticipation, suggesting a neural basis for anhedonia in this population.

Why this might work

In adolescents with nonsuicidal self-injury and depression, the brain's reward center does not respond properly when expecting something good because dopamine signals are weak and the connection between the thinking part of the brain and the reward center is broken. This makes them feel empty and numb, so they hurt themselves to trigger a strong chemical surge that briefly fills the void.

Verified mechanismbased on 1 study

What the research says

1 study
  1. Study: Beyond distress relief: the Anhedonic Subtype of nonsuicidal self-injury and the imperative for Positive Affect Treatment

    This study says that teens who hurt themselves and feel empty or numb often have a brain reward system that doesn’t light up when they expect something good — which might explain why they don’t feel pleasure. It uses existing brain scan data to back this up.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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