Melatonin helps protect the cells lining your blood vessels by boosting their energy production and reducing harmful cellular stress. This process stops these cells from dying in a highly inflammatory way, keeping your blood vessels healthier and more resilient.

What we have found so far suggests that melatonin may help protect the cells that line your blood vessels. Our current analysis shows the evidence leans toward this protective effect. We reviewed one assertion and found that 3 studies support, 0 studies refute [1]. The evidence we have reviewed suggests that melatonin works by improving how these cells produce energy. It also appears to lower harmful cellular stress, which is damage that builds up inside cells over time. When this stress is reduced, the cells are less likely to die in a highly inflammatory way. This means the cells break down in a manner that does not trigger widespread swelling or irritation in nearby tissue. This process may keep your blood vessels healthier and more resilient. We want to be clear that this is a partial view. Our analysis is based on the research available right now, and it will improve as more studies are published. The evidence we have reviewed leans toward melatonin offering protection, but we cannot say this is a final answer. Not every study has been examined yet, and biological responses can vary. Based on what we have reviewed so far, melatonin shows promise for supporting blood vessel health by reducing cellular stress and preventing inflammatory cell death. If you are considering melatonin for this purpose, talk to a healthcare provider about whether it fits your routine. Starting with a low dose and monitoring how you feel is a sensible approach. We will continue tracking new research to update our findings as they come in.