Analysis Version
v1
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mechanistic
Analysis v1
Strong Support

C8, a type of chemical, sticks to certain receptors in the body and messes with hormone signals and how genes control hormone production, which can cause hormone problems.

4
Pro
0
Against

Evidence from Studies

Supporting (1)

4

Community contributions welcome

4

Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays.

Cross-Sectional Study
In Vitro
2023 Aug 1

The study shows that PFOA (also called C8) turns on a protein called PPARα, which changes how genes work in liver cells. This supports the idea that C8 can interfere with hormone-related processes in the body.

Contradicting (1)

0

Community contributions welcome

6

The role of PPAR alpha in perfluorooctanoic acid induced developmental cardiotoxicity and l-carnitine mediated protection-Results of in ovo gene silencing.

Cross-Sectional Study
Animal
2017 Dec

The study looks at how a chemical called PFOA affects baby chicken hearts, not hormones. So it doesn't show whether PFOA disrupts hormone systems like the claim says.

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