mechanistic
Analysis v1
Strong Opposition

Cancer cells grow differently depending on how stiff the collagen around them is: on hard collagen, they turn on a growth switch (YAP/TAZ); on soft collagen, they use a different switch (MRTF/SRF).

0
Pro
1
Against

Evidence from Studies

Supporting (0)

0

Community contributions welcome

No supporting evidence found

Contradicting (1)

1

Community contributions welcome

This study talks about where collagen comes from and how it's used in medicine, but it doesn't say anything about how stiff or soft collagen affects cancer cell growth or the inside signals they use.