The Claim
CD8+ memory T cells express SLC25A29 and SLC14A1 transporters to shuttle urea cycle intermediates across mitochondrial membranes under laboratory conditions.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
CD8+ memory T cells contain specific transport proteins called SLC25A29 and SLC14A1 that move urea cycle intermediates across mitochondrial membranes in laboratory settings.
See the scientific wording
CD8+ memory T cells express SLC25A29 and SLC14A1 transporters to shuttle urea cycle intermediates across mitochondrial membranes under laboratory conditions.
CD8+ memory T cells take in ammonia and convert it into harmless waste products using two connected cycles inside the cell. To do this, they move key molecules like arginine into the mitochondria using a specific transporter called SLC25A29, where it gets broken down into urea and ornithine. Another transporter, SLC14A1, moves urea and other nitrogen compounds out of the mitochondria so they can be safely removed from the cell. This process clears toxic ammonia and allows the T cells to survive and function as long-term memory cells.
What the research says
1 studyStudy: Ammonia detoxification promotes CD8^+ T cell memory development by urea and citrulline cycles
The study shows that CD8+ memory T cells clean up toxic ammonia using a special cycle that needs to move molecules in and out of the cell’s power plants (mitochondria), which likely requires special transporter proteins — even if the exact names weren’t tested.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.