Creatine gets into human cells in two ways: one is like a precise lock-and-key system that works well at low levels, and the other is a more general process that kicks in when there's a lot of...

Your body has a special door called CRT-1 that lets creatine into muscle cells by using salt particles (sodium and chloride) as helpers — it doesn’t need potassium to do this, and it can pull creatine in even when there’s already a lot inside the cell.

Imagine creatine needs to get into cells through a special door that only opens one way. When creatine teams up with salt ions (sodium and chloride), the door becomes much less likely to let creatine slip back out, so it keeps moving in even when there’s already a lot of creatine inside the cell.

Your body has a special gate called CRT-1 that pulls creatine into muscle and brain cells by using salt particles as helpers, so your cells can store energy for when you need it most—like during a tough workout or thinking hard.

Your muscles use a special door called SLC6A8 to let creatine in, and this door only works when there’s more sodium outside the cell than inside — like a pump that needs salt to open.

When creatine teams up with salt particles (sodium and chloride), it becomes much less likely to stick around inside the cell, so it can keep getting pulled in from outside—even when there’s already a lot of creatine inside.