When cells lose water, their mitochondria become less able to break down glucose for energy due to reduced function of specific proteins that transport pyruvate and depend on water.

From: The Crazy Effect of Drinking Ice Water on Insulin Resistance

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What this claim means

When cells lose water, their mitochondria become less able to break down glucose for energy due to reduced function of specific proteins that transport pyruvate and depend on water.

See the technical phrasing

Cellular dehydration impairs mitochondrial glucose oxidation by disrupting the function of pyruvate transporters and other water-sensitive mitochondrial proteins.

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