Certain receptors on immune cells grab onto antibodies attached to germs, helping the cells swallow them up so they can be broken down and shown to other immune cells.
Scientific Claim
FcγRI, FcγRIIA, FcγRIIIA, and FcγRIV are expressed on human and mouse antigen-presenting cells, including dendritic cells and macrophages, and bind IgG immune complexes to facilitate their internalization.
Original Statement
“In humans, three groups of FcγRs have been described across a variety of cell types: FcγRI, FcγRIIA/B, FcγRIIIA/B (30). These are expressed in differing combinations at the surface membrane of the various immune cells (31). In the case of FcγRI, these include macrophages, neutrophils, eosinophils and DCs. For FcγRIIA, cell types include macrophages, neutrophils, eosinophils, platelets, and Langerhans cells as well as conventional, but not plasmacytoid, DCs (32). FcγRIIIA is found on natural killer (NK) cells and macrophages, as reviewed elsewhere (33). ... Cell-type specific expression of mouse FcγRs (the activating FcγRI, FcγRIII, FcγRIV, and the inhibitory FcγRIIB) has also been assessed. Conventional mouse DCs were found to express FcγRI, FcγRIII, FcγRIV, and FcγRIIB (36, 37).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The claim describes established receptor expression patterns from multiple primary studies cited in the review. The use of definitive language is appropriate because these are well-documented cellular phenotypes.
Evidence from Studies
Supporting (1)
This study says that certain immune system receptors (FcγRs) grab onto antibodies attached to germs or debris and pull them inside cells that show these invaders to other immune cells — exactly what the claim says.