When antibodies tag a germ, immune cells that show antigens to killer T cells do a much better job of it than if the germ was just floating around without tags.
Scientific Claim
FcγR-mediated internalization of IgG-opsonized antigens enhances cross-presentation on MHC class I molecules in dendritic cells compared to fluid-phase uptake of unopsonized antigen.
Original Statement
“Regnault et al. demonstrated in a mouse DC system that the internalization of IgG-ICs leads to an enhancement of cross-presentation compared to the fluid phase uptake of 'naked,' non-IgG opsonized antigen (59). Importantly, FcγR engagement of the antigen-IgG complex was critical as such enhancement in presentation was not mimicked by the DC being exposed to an irrelevant IC in conjunction with the fluid phase uptake of the antigen.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The claim is based on controlled in vitro experiments comparing antigen presentation outcomes. The enhancement is demonstrated as a direct functional consequence of FcγR engagement.
Evidence from Studies
Supporting (1)
This study says that when antibodies stick to germs, immune cells grab them more efficiently and process them in a way that helps activate killer T cells—better than if the germs were just floating around unattached.