mechanistic
Analysis v1
Strong Support
Changing a specific amino acid in the human type 2 deiodinase enzyme reduces its ability to take up selenium-75 in laboratory-grown human cells, but does not change its ability to remove iodine from thyroid hormones, suggesting this amino acid is not required for the enzyme's core function in this setting.
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0
Evidence from Studies
Supporting (1)
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Community contributions welcome
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Scientists changed a tiny part of an enzyme that uses selenium, and while the enzyme no longer grabbed selenium as well, it still worked fine at doing its job. So that part isn’t needed for the enzyme to function.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.