Too much insulin makes your body's stress system active, speeding up your heart and tightening blood vessels, which raises blood pressure.

Context Details

Domain

cardiology

Population

human

Subject

chronic insulin elevation

Action

activates

Target

sympathetic nervous system leading to increased cardiac output and vasoconstriction

Intervention Details

Type: other

Evidence from Studies

Supporting (1)

14

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

Randomized Controlled Trial

Animal

2011 May

This study helps understand how the body controls blood pressure and sugar levels, which is related to how insulin affects the nervous system and blood pressure.

Contradicting (1)

13

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Cohort Study

Animal

2018 Sep 22

This study suggests that long-term insulin use may have negative effects on blood vessels, contradicting the idea that insulin always helps blood pressure.