When people take nitrate medications for a long time, their body gets used to them and they stop working as well—this happens because the drugs cause cellular stress, damage the energy factories in...
Strongly supported
Multiple high-quality studies back this claim.
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When people take nitrate medications for a long time, their body gets used to them and they stop working as well—this happens because the drugs cause cellular stress, damage the energy factories in...
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Chronic administration of exogenous nitric oxide donors, such as nitrates, induces tolerance through the mechanisms of oxidative stress, mitochondrial dysfunction, and desensitization of soluble guanylyl cyclase, resulting in a diminished vasodilatory response.
What the research says
Supports
1 study
Study: Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress
This study provides evidence supporting the claim.
Contradicts
0 studies
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies