If your body makes too much cortisol for too long, your adrenal glands can get worn out and stop working well when you actually need to handle stress.
Evidence from Studies
Supporting (2)
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Optogenetic induction of chronic glucocorticoid exposure in early‐life leads to blunted stress‐response in larval zebrafish
The study shows that when young zebrafish are made to produce too much cortisol for a long time, their bodies become worse at responding to new stress, just like the claim says happens in people.
The hypothalamo–pituitary–adrenal axis in chronic fatigue syndrome and fibromyalgia syndrome
The study looks at people with long-term stress-related illnesses and finds their bodies produce less cortisol over time, which matches the idea that constant stress can wear out the body's stress response system.
Contradicting (0)
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Gold Standard Evidence Needed
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