When blood sugar stays too high for a long time, it chemically sticks to the proteins in your blood vessels and damages them. Over time, this damage weakens your arteries and tiny blood vessels, which can eventually lead to serious problems with your kidneys, eyes, and leg circulation.

What we have found so far suggests that long-term high blood sugar may damage blood vessels and contribute to issues with the kidneys, eyes, and leg circulation. Our current analysis shows that the evidence we have reviewed leans toward this connection, though we are still building a complete picture. We analyzed the available research and found 1 study supports this idea, and 0 refute it [1]. When blood sugar stays elevated for extended periods, it can chemically stick to proteins inside your blood vessels. This slow process gradually weakens both your larger arteries and the tiny vessels that reach deep into your tissues. Over time, this weakening can create challenges for your kidneys, your vision, and the blood flow to your legs. The evidence we have reviewed leans toward the idea that keeping blood sugar stable helps protect these delicate networks. We do not have enough studies to say how quickly this damage happens or exactly how it varies from person to person. Our current analysis shows that the available research points in one direction, but we will continue to track new findings as they emerge. For now, the practical takeaway is simple. Monitoring your blood sugar levels and following your healthcare provider’s guidance on diet and activity can help keep your vessels healthy. Small, consistent steps to manage your numbers may support better circulation and protect your organs over time.