The Claim

Exposure to trans-fatty acids is associated with increased hepatic GPAM expression, elevated liver triglyceride content, and reduced visceral adipose tissue in humans and mice.

Source: GPAM upregulation enhances hepatic fat deposition and reduces visceral adipose tissue in response to trans-fatty acids

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
40score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

Consuming trans-fatty acids is linked to higher levels of GPAM in the liver, more fat stored in the liver, and less fat stored in visceral adipose tissue in humans and mice.

See the scientific wording

Exposure to trans-fatty acids is associated with increased hepatic GPAM expression, elevated liver triglyceride content, and reduced visceral adipose tissue in humans and mice, suggesting a role for GPAM in redirecting fat storage from adipose tissue to the liver.

Why this might work

Trans-fatty acids enter liver cells and trigger the production of a protein called GPAM, which speeds up the creation of fat molecules inside the liver. This causes more fat to build up in the liver and less fat to be stored in the belly area.

Verified mechanismbased on 1 study

What the research says

1 study
  1. Study: GPAM upregulation enhances hepatic fat deposition and reduces visceral adipose tissue in response to trans-fatty acids

    This study found that eating trans fats makes the liver produce more of a protein called GPAM, which causes more fat to build up in the liver and less fat to stay in the belly area. It’s like trans fats trick the body into storing fat where it shouldn’t.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.