Creatine helps shuttle energy from where it's made in the cell to where it's needed, kind of like a rechargeable battery moving power from a charger to your phone.
Evidence from Studies
Supporting (4)
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High-energy phosphate transfer in human muscle: diffusion of phosphocreatine.
The study shows that the molecule phosphocreatine can travel far enough in muscle cells to carry energy from where it's made to where it's used, which supports the idea that creatine helps move energy around the cell.
Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle
The study shows that creatine helps move energy from where it's made in the cell to where it's used, especially after exercise, which supports the idea that creatine acts like a battery shuttle.
Creatine transporter (SLC6A8) knockout mice exhibit reduced muscle performance, disrupted mitochondrial Ca2+ homeostasis, and severe muscle atrophy
The study looks at mice that can't take up creatine into their muscles and finds their energy production and muscle function are badly impaired, which supports the idea that creatine helps move energy around in cells.
Chronic exposure of rats to hypoxic environment alters the mechanism of energy transfer in myocardium.
The study shows that when creatine doesn’t work as well in heart cells, energy transfer gets worse, which supports the idea that creatine normally helps move energy where it’s needed.
Contradicting (0)
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Gold Standard Evidence Needed
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