Your body makes creatine in two steps: first, it combines glycine and arginine to make a middle substance, then it adds a methyl group to turn that into creatine.

Evidence from Studies

Supporting (1)

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Crystal structure and mechanism of human L‐arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis

Computational/Algorithm Study

In Vitro

1997 Jun 16

The study looks at the first step of how the body makes creatine and shows that the enzyme responsible works just as the claim says it does.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Similar Assertions

Taking creatine supplements might tell your body to make less of its own creatine by turning down a key enzyme, kind of like turning off a faucet when you're already getting water from another source.

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