The Claim
Creatine binds to the human creatine transporter (hCRT) at a central substrate-binding site formed by transmembrane helices TM1, TM3, TM6, and TM8, with key stabilizing interactions mediated by residues F68, C144, Y148, and F315 through π–π stacking and hydrogen bonding that accommodate the zwitterionic form of creatine.
What the research says
Not yet evaluated
We are still looking at what the research says.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Creatine sticks to a special spot in a human protein using specific handholds, kind of like a key fitting into a lock, with certain parts of the protein helping hold it in place using molecular Velcro and tiny magnets.
See the scientific wording
Creatine binds to the human creatine transporter (hCRT) in a central substrate-binding site coordinated by transmembrane helices TM1, TM3, TM6, and TM8, with key interactions involving residues F68, C144, Y148, and F315 that stabilize the zwitterionic substrate through π–π stacking and hydrogen bonding.
What the research says
1 studyThe study took detailed pictures of how creatine sticks to its transporter in human cells and showed that it grabs onto specific spots in the protein, just like the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.