A specific part of a protein called Y148 grabs onto creatine, while a sodium ion tugs on another part of the protein, and together they snap the transporter shut—like a latch closing to trap creatine inside.

Evidence from Studies

Supporting (1)

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Probing binding and occlusion of substrate in the human creatine transporter‐1 by computation and mutagenesis

Computational/Algorithm Study

2024 Jan

Scientists found that a specific part of the creatine transporter (Y148) holds onto creatine, while a sodium ion pulls part of the transporter shut — like a latch — and this is exactly how the claim says it works.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Probing binding and occlusion of substrate in the human creatine transporter‐1 by computation and mutagenesis

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DOI: 10.1002/pro.4842

Similar Assertions

Imagine creatine needs to get into cells through a special door that only opens one way. When creatine teams up with salt ions (sodium and chloride), the door becomes much less likely to let creatine slip back out, so it keeps moving in even when there’s already a lot of creatine inside the cell.

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73%

When creatine teams up with salt particles (sodium and chloride), it becomes much less likely to stick around inside the cell, so it can keep getting pulled in from outside—even when there’s already a lot of creatine inside.

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70%