Creatine helps protect tiny muscle cells from shrinking when they're starved, but only when there's no sugar around — it seems to work only when energy is low.

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Evidence from Studies

Supporting (1)

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The regulating pathway of creatine on muscular protein metabolism depends on the energy state.

Cross-Sectional Study

Animal

2022 May 1

The study shows that creatine helps prevent muscle breakdown in starved chick muscle cells, but only when there's no glucose around. When glucose is added, creatine doesn't help anymore.

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Source Study

The regulating pathway of creatine on muscular protein metabolism depends on the energy state.

Score: 8

DOI: 10.1152/ajpcell.00447.2021

Similar Assertions

When chicken muscle cells are starved, adding creatine seems to lower levels of two proteins that make muscles waste away — this might mean creatine helps protect muscles when there's not enough energy.

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In chicken muscle cells with normal energy, adding creatine seems to boost protein building and turn on key muscle growth switches in the cells.

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When chicken muscle cells are starved, adding creatine seems to boost a key protein for energy and reduce harmful molecules, which might help the cells' powerhouses work better under stress.

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