Creatine supplementation is associated with a reduction in the rate of cognitive decline in Alzheimer’s disease by up to 30 percent.
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Creatine supplementation may slow the progression of Alzheimer’s disease by up to 30 percent.
Very strong evidence
Mixed evidence2 moderate-quality studies support this claim, so treat these as early signals rather than settled science.
What the research says
2 studies reviewedSupporting (2)
Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition
Randomized Controlled TrialHuman2025
This small study found that Alzheimer’s patients who took creatine supplements for two months got a little better at remembering things and reading words. It doesn’t prove it stops the disease by 30%, but it does show creatine might help the brain work a bit better.
Bioenergetic data from a creatine monohydrate pilot trial in Alzheimer's disease
Cross-Sectional StudyHuman2026
This study found that taking creatine helped brain cells make more energy in people with Alzheimer’s, which might help slow how fast their memory gets worse. But it didn’t measure memory directly, so we can’t say for sure it cuts decline by 30%.
Contradicting (0)
No contradicting studies found yet
That doesn't mean it's settled — it just means no study has tested the opposite.
Quality-weighted scoring: we follow the GRADE framework — each study is rated High, Moderate, Low, or Very Low based on study design, methodology rigor, and risk of bias. A single high-quality RCT can outweigh several weaker observational studies.
Scores reflect study quality, not just count.
Taking creatine raises levels of a molecule in the brain that helps cells quickly make more energy. This extra energy lets brain cells work better, especially when they need to communicate or maintain their function, which helps memory and thinking stay sharper.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 2 supporting studies
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