Cutting off the end of a hormone called exendin-4 doesn’t make it break down faster in anesthetized pigs, so that part probably doesn’t matter much for how long the hormone lasts in their bodies.

14

Pro

0

Against

Evidence from Studies

Supporting (1)

14

Community contributions welcome

14

The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs.

Cross-Sectional Study

Animal

2013 Feb 10

The study shows that cutting off part of a hormone called exendin-4 doesn’t make it break down faster in pigs, just like the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs.

Score: 14

DOI: 10.1016/j.regpep.2012.12.012

Similar Assertions

In pigs under anesthesia, adding a small piece from a lizard hormone to a blood sugar hormone makes it last much longer in the body.

14

0

80%

In lab tests with rat tissues, a substance called exendin-4 breaks down way faster in the kidney than in the liver — just a few minutes in the kidney versus over an hour and a half in the liver.

8

0

74%

In pigs under anesthesia, certain diabetes-related peptides like exendin-4 are removed from the body only by the kidneys, while others like GLP-1 are cleared by both the kidneys and other body tissues — showing they leave the body in different ways.

14

0

71%