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Claim
Strong Support
quantitative
Analysis v3

Cutting off the end of a hormone called exendin-4 doesn’t make it break down faster in anesthetized pigs, so that part probably doesn’t matter much for how long the hormone lasts in their bodies.

14
Pro
0
Against

Evidence from Studies

Supporting (1)

14

Community contributions welcome

14

The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs.

Cross-Sectional Study
Animal
2013 Feb 10

Contradicting (0)

0

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No contradicting evidence found

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Source Study

The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs.

Score: 14
DOI: 10.1016/j.regpep.2012.12.012

Similar Assertions

In pigs under anesthesia, adding a small piece from a lizard hormone to a blood sugar hormone makes it last much longer in the body.

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0
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In lab tests with rat tissues, a substance called exendin-4 breaks down way faster in the kidney than in the liver — just a few minutes in the kidney versus over an hour and a half in the liver.

8
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In pigs under anesthesia, certain diabetes-related peptides like exendin-4 are removed from the body only by the kidneys, while others like GLP-1 are cleared by both the kidneys and other body tissues — showing they leave the body in different ways.

14
0
71%