The Claim
A computational model that incorporates circadian regulation of T4-to-T3 conversion in both thyroidal and peripheral tissues can reproduce human circadian thyroid hormone profiles, including the phase relationship between TSH and free T3 and the relative amplitude of T3 versus T4, with peripheral conversion preceding thyroidal TSH action by approximately 3 hours.
What the research says
Not yet evaluated
We are still looking at what the research says.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
There's a computer model that can mimic how our thyroid hormones rise and fall during the day, and it works by timing how the body converts one hormone into another in different places, with the body's tissues getting a 3-hour head start over the thyroid gland.
See the scientific wording
Human circadian thyroid hormone profiles, including the phase relationship between TSH and free T3 and the relative amplitude of T3 versus T4, can be reproduced by a model incorporating combined circadian regulation of T4-to-T3 conversion in both thyroidal and peripheral tissues, with peripheral conversion leading thyroidal TSH action by approximately 3 hours.
What the research says
1 studyThe study tested a model of how the body controls thyroid hormones over the day and found that timing matters: when the body converts one hormone to another in different organs at slightly different times, it matches real human patterns.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
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