The Claim

Nicotinamide riboside supplementation at 1000 parts per million in the diet, administered to UM-HET3 mice of both sexes beginning at 8 months of age, did not demonstrate a statistically significant increase in lifespan in either males or females when data were pooled across three independent testing sites.

Source: 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
13score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

Scientists fed mice a special vitamin supplement called nicotinamide riboside in their food starting when the mice were middle-aged, then tracked how long they lived. The supplement didn't make the mice live longer.

See the scientific wording

Nicotinamide riboside (1000 ppm in diet) administered to UM-HET3 mice of both sexes starting at 8 months of age was not associated with significant lifespan extension in either males or females in pooled data from three testing sites

What the research says

1 study
  1. Study: 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

    The study tested nicotinamide riboside in the same type of mice (UM-HET3) mentioned in the claim and found it did not make the mice live longer. This matches what the claim says about no significant lifespan extension.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

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