Diabetic rats had weaker heart mitochondria energy production, but MOTS-c treatment helped improve it back to normal levels.
Scientific Claim
In a rat model of type 2 diabetes, mitochondrial oxygen flux during oxidative phosphorylation with complex I and II substrates was 13% lower in untreated diabetic rats compared to controls, and MOTS-c treatment was associated with higher flux levels in diabetic rats.
Original Statement
“In untreated diabetic rats, mass-specific oxygen flux from carbohydrate-supported substrates (including malate, glutamate and pyruvate) was 13% lower in CI + CII OXP respiratory state than in the control.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design is an animal cohort, which can only show association. 'Was associated with' correctly reflects the evidence without implying causation.
Evidence from Studies
Supporting (1)
Mitochondria-derived peptide MOTS-c restores mitochondrial respiration in type 2 diabetic heart