Diet and exercise are linked to changes in the course of autoimmune thyroid disease.
Mechanism
Synthesis from 2 studies
Eating the right foods reduces inflammation and fat tissue, which stops the immune system from attacking the thyroid and lets it make more active hormone. Exercise likely does the same thing by calming the immune system and reducing fat, but this has not been proven in detail.
Most probable mechanism
Eating foods that reduce inflammation and oxidative stress lowers the body's immune attack on the thyroid, allows the thyroid to produce more active hormone, and helps the body convert the stored hormone into its active form by reducing fat tissue and calming immune cells.
Elimination of gluten reduces intestinal permeability and prevents cross-reactivity between gliadin peptides and thyroid antigens, decreasing activation of autoreactive T and B cells
Intake of omega-3 fatty acids, polyphenols, selenium, and antioxidants suppresses NF-κB and MAPK signaling pathways, reducing production of pro-inflammatory cytokines and reactive oxygen species in thyroid tissue
Reduction in adipose tissue mass decreases secretion of leptin and IL-6, lowering systemic inflammation and reducing infiltration of T cells and macrophages into the thyroid gland
Decreased oxidative stress and inflammation preserve thyroid follicular cell integrity and enhance deiodinase type 2 activity, increasing conversion of thyroxine (T4) to triiodothyronine (T3)
Lower autoantibody levels and reduced thyroid inflammation prevent antibody-mediated destruction of thyroid follicular cells, sustaining hormone synthesis capacity
Less supported by current evidence, but not ruled out
Physical activity reduces fat tissue and calms the immune system, which decreases the attack on the thyroid and helps it function better.
Regular physical activity reduces visceral adipose tissue mass, lowering leptin and IL-6 secretion
Exercise promotes redistribution of immune cells away from inflammatory sites, reducing lymphocytic infiltration in the thyroid
Increased muscle-derived anti-inflammatory myokines enhance systemic antioxidant capacity and suppress Th17 responses
Evidence from Studies
Supporting (2)
Community contributions welcome
Evaluation of the effect of gluten‐free diet and Mediterranean diet on autoimmune system in patients with Hashimoto's thyroiditis
Contradicting (0)
Community contributions welcome
Gold Standard Evidence Needed
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