The Claim

The demographic composition of a general practice catchment area strongly influences recruitment efficiency, with each one percentage point increase in the proportion of residents aged 70 years or older associated with a 10% increase in the likelihood of a general practitioner successfully randomising at least one trial participant. This highlights the critical importance of aligning trial target demographics with local population age structures to optimize enrollment rates.

Source: Recruiting general practice patients for large clinical trials: lessons from the Aspirin in Reducing Events in the Elderly (ASPREE) study

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
62score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Description
1 study reviewed

What the research says

1 study

  1. Study: Recruiting general practice patients for large clinical trials: lessons from the Aspirin in Reducing Events in the Elderly (ASPREE) study

    Logistic regression analysis of practice postcode demographics revealed a dose-response relationship between local elderly population density and recruitment success. The adjusted odds ratio of 1.10 per percentage point indicates that demographic targeting is a powerful predictor of enrollment efficiency for age-specific trials.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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