The Claim

Acute resistance exercise consisting of 20 sets of 10 repetitions of leg extensions and flexions at 75% of one-repetition maximum increases myofibrillar and sarcoplasmic protein synthesis by two- to threefold in the exercised leg of young, healthy men, demonstrating a robust anabolic response to high-volume resistance training in human skeletal muscle.

Source: No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
30score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Doing a tough leg workout with lots of sets makes your leg muscles start building new proteins much faster—2 to 3 times more than usual—right after the workout.

See the scientific wording

Acute resistance exercise (20 sets of 10 leg extensions and flexions at 75% 1RM) increases myofibrillar and sarcoplasmic protein synthesis by two- to threefold in the exercised leg of young, healthy men, indicating a robust anabolic response to high-volume resistance training in human skeletal muscle.

What the research says

1 study
  1. Study: No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise.

    The study found that intense leg exercise boosts muscle protein creation by two to three times, just like the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.