Doing intense drop-set workouts until your legs can't do another rep causes clear signs of muscle tiredness in beginners, based on electrical signals from the muscles — making it a solid way to push muscles hard during a workout.

When beginners do intense leg press workouts to the point of exhaustion, their muscles get increasingly tired, and this shows up as changes in muscle activity signals — some muscles work harder, others change how they fire, and these shifts tell us fatigue is building up.

Lifting weights until you can't do another rep leaves you much more tired during and after the workout than stopping a few reps short — even if both methods build muscle equally.

If you lift weights until you literally can't do another rep, you'll feel more tired right after than if you stop a couple reps before failure — even if you're someone who regularly lifts weights.

Drop sets made guys feel more tired and their muscles puff up more after one workout, but they didn’t make them stronger in the long run than regular sets.

Going all the way to muscle burnout during weight training tires out your brain and nerves more than stopping just before total exhaustion.