The Claim
In untrained men, performing five sets of 6-repetition maximum leg press exercise in a fasted state is associated with a sixfold increase in p70S6k phosphorylation and a 55-fold increase in S6 ribosomal protein phosphorylation in skeletal muscle 30 minutes post-exercise, compared to baseline, suggesting that higher resistance training volume more strongly activates the mTORC1 signaling pathway involved in protein synthesis.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When guys who don’t normally lift weights do a tough leg workout on an empty stomach, their muscles show a big spike in two specific signals that tell the body to build more muscle, and this might mean doing more sets makes those signals even stronger.
See the scientific wording
In untrained men, performing five sets of 6-repetition maximum leg press exercise in a fasted state is associated with a sixfold increase in p70S6k phosphorylation and a 55-fold increase in S6 ribosomal protein phosphorylation in skeletal muscle 30 minutes post-exercise, compared to baseline, suggesting that higher resistance training volume more strongly activates the mTORC1 signaling pathway involved in protein synthesis.
What the research says
1 studyThe study found that when untrained men did five tough leg presses on an empty stomach, their muscle signaling for building protein jumped way up—exactly as the claim said it would.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.