The Claim
High-fatiguing single-set resistance exercise produces the weakest acute signaling response across multiple anabolic pathways in young men when compared to maximal eccentric or standard multi-set protocols matched for total time under tension.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When young men do one set of really tiring weightlifting, it gives the smallest boost to muscle-building signals right after exercise, compared to doing max-stretch moves or multiple sets that take the same total time.
See the scientific wording
High-fatiguing single-set resistance exercise produces the weakest acute signaling response across multiple anabolic pathways in young men when compared to maximal eccentric or standard multi-set protocols matched for total time under tension.
What the research says
1 studyThe study found that doing one set of very tiring weightlifting gave the smallest boost to muscle-building signals compared to other methods with the same total effort time, just like the claim said.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.