The Claim

A single 500 mL dose of L-citrulline-enriched watermelon juice containing 3.45 g L-citrulline significantly reduces plasma lactate concentration immediately after a half-marathon in amateur male runners compared to placebo.

Source: Biochemical, physiological, and performance response of a functional watermelon juice enriched in L-citrulline during a half-marathon race

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
61score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

Amateur male runners who drink 500 mL of L-citrulline-enriched watermelon juice with 3.45 g L-citrulline after a half-marathon have 22% lower plasma lactate levels immediately after finishing compared to those who drink a placebo.

See the scientific wording

A single 500 mL dose of L-citrulline-enriched watermelon juice (3.45 g L-citrulline) significantly lowers plasma lactate concentration immediately after a half-marathon in amateur male runners, reducing lactate levels by approximately 22% compared to placebo.

Why this might work

L-citrulline enters the bloodstream and is converted to arginine, which triggers the production of nitric oxide. Nitric oxide widens blood vessels, improving oxygen delivery to muscles. At the same time, L-citrulline helps remove ammonia built up during intense exercise. Less ammonia means muscles rely less on anaerobic energy production, which cuts down the amount of lactate made. More oxygen and less ammonia allow muscles to burn fuel with oxygen instead of producing lactate.

Verified mechanismbased on 1 study

What the research says

1 study
  1. Study: Biochemical, physiological, and performance response of a functional watermelon juice enriched in L-citrulline during a half-marathon race

    Drinking this special watermelon juice before a half-marathon helped runners have 22% less lactate in their blood right after finishing, meaning their bodies didn’t have to work as hard without oxygen during the race.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.