During exercise, skeletal muscle releases signaling molecules like IL-6, FGF21, and GDF15 that influence metabolism, immune function, and appetite in other organs, but it is not yet proven that these...

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Supporting (1)

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Decoding the Endocrine Code of Skeletal Muscle: Myokines, Exerkines, and Inter-Organ Crosstalk in Metabolic Health and Disease

Narrative Review

2026 Feb 8

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Decoding the Endocrine Code of Skeletal Muscle: Myokines, Exerkines, and Inter-Organ Crosstalk in Metabolic Health and Disease

Score: 1

DOI: 10.3390/cells15040318