Cutting calories by 14% for two years might reprogram fat tissue in middle-aged people in ways that reduce inflammation and boost energy burning, which could help them stay healthier longer.

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Evidence from Studies

Supporting (1)

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Caloric restriction in humans reveals immunometabolic regulators of health span

Cohort Study

Human

2022 Feb 11

The study looked at people who ate 14% less food for 2 years and found their fat tissue changed in ways that reduce inflammation and improve energy use, which may help people stay healthier as they age.

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Source Study

Caloric restriction in humans reveals immunometabolic regulators of health span

Score: 37

DOI: 10.1126/science.abg7292

Similar Assertions

If healthy middle-aged people eat 14% less food for two years, a certain gene in their fat tissue becomes less active, and this change is linked to better energy use, less body-wide inflammation, and healthier metabolism — meaning this gene might help the body adapt to eating less.

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