Eating earlier in the day for 4 days made the body more responsive to insulin in the morning, as shown by lower insulin resistance scores and increased expression of a key insulin signaling gene.
Scientific Claim
Early time-restricted feeding increased morning fasting insulin sensitivity as measured by HOMA-IR reduction of 0.73 units and increased IRS2 gene expression by 25% in overweight adults after 4 days of intervention.
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
This is a randomized controlled trial with direct measurements of insulin sensitivity markers and gene expression. The verb 'increased' is appropriate for these specific short-term effects.
Source Excerpt
“In the morning, eTRF lowered fasting glucose and insulin by 2 ± 1 mg/dl (p = 0.02) and 2.9 ± 0.4 mU/l (p < 0.0001), respectively. As a result, HOMA-IR was lower by 0.73 ± 0.11 (p < 0.0001). This was accompanied by a 25 ± 9% increase in IRS2 gene expression (p = 0.01).”
Evidence from Studies
Supporting Evidence (1)
The study measured fasting glucose, insulin, and HOMA-IR in the morning, showing statistically significant improvements in insulin sensitivity metrics. The gene expression data for IRS2 further supports this finding.
Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans