Taking nitrate supplements for 16 weeks doesn’t seem to change cholesterol, good/bad fats in the blood, or inflammation markers in people with early high blood pressure—so it doesn’t help those things in this group.

A double-blind, placebo-controlled RCT with 100+ participants diagnosed with early-stage hypertension, randomly assigned to receive either 400 mg/day dietary nitrate, 50 mg/day dietary nitrate, or placebo for 16 weeks, with fasting serum lipids (total cholesterol, LDL, HDL, triglycerides) and hs-CRP measured at baseline, week 8, and week 16.

A single-center RCT with 50 participants with early-stage hypertension receiving either 400 mg/day nitrate or placebo for 16 weeks, with serum lipids and hs-CRP measured at baseline and endpoint, using a crossover design with 4-week washout.

A prospective cohort study following 200 individuals with early-stage hypertension over 16 weeks, tracking those who self-select into dietary nitrate supplementation (400 mg/day or 50 mg/day) versus non-supplementers, measuring serum lipids and hs-CRP at baseline and endpoint.

A retrospective analysis comparing lipid and hs-CRP levels in individuals with early-stage hypertension who previously took dietary nitrate supplements (400 mg/day or 50 mg/day for 16 weeks) versus those who did not, using medical records.

A case series reporting lipid and hs-CRP changes in 15–20 individuals with early-stage hypertension who took 400 mg/day or 50 mg/day dietary nitrate for 16 weeks, with pre- and post-intervention measurements.