mechanistic
Analysis v1
EGCG, a compound in green tea, sticks really well to a human enzyme called COMT, but it doesn’t fit right for the enzyme to change it—so it blocks the enzyme instead of getting modified itself.
Evidence from Studies
Supporting (1)
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Molecular modelling study of the mechanism of high-potency inhibition of human catechol-O-methyltransferase by (–)-epigallocatechin-3-O-gallate
Computational/Algorithm Study
2008 FebEGCG sticks really well to the COMT enzyme, blocking it effectively, but its shape doesn’t fit right for the enzyme to methylate it, so it gets stuck as an inhibitor instead of being changed.
Contradicting (0)
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No contradicting evidence found
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